Basic Information
VIS ID
TVIS20000721
Fusion event
HPV-GPC5 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr13
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
92294945/91642691 (Hg38)
End
92294945/91642691 (Hg38)
Location type
Intronic
Target gene
GPC5
miRNAs that regulate target gene
hsa-mir-217 ; hsa-mir-190b ; hsa-mir-190a-5p ; hsa-mir-20a-3p ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-6868-3p ; hsa-mir-6749-3p ; hsa-mir-642a-5p ; hsa-mir-3124-3p ; hsa-mir-4469 ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-6809-3p ; hsa-mir-1238-3p ; hsa-mir-4753-3p ; hsa-mir-670-3p ; hsa-mir-942-5p ; hsa-mir-130b-5p ; hsa-mir-4637 ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-297
Nearest miRNA
hsa-mir-1297/Upstream/291300; hsa-mir-1267/Downstream/847472;
Nearest TSS
ENST00000623511/Upstream/244084; ENST00000618596/Downstream/50495;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/243229, chr13-CpG: 139/Downstream/1584301
Nearest cancer related gene
GPC5(TSG, No orient, 0)
Upstream sequence
GAGCAAACAGCATTGGGTAACAGGGCCATGCCCCAAAACCTGGAAGCCAGGTTCTCCTTTTCTTCCTCTTGGTGGACACAGTCTTAACCGCCCACAAAAG
Downstream sequence
CTAGACCTGAGGCACCTTGGCCTGCTCAGTTATTTCCAGGATGGTTGTGCAGACACCGCAGTCACACATGAGGAGGGCTGACCGGTGAGTTCAGGCGCAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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