Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene18416891871424198220718676901874689186200118649871882495188405418657771867257189883818999631895569189661318814611882490190522719060921890835189163018874011888109187860018790001880201188060018809531881327188550618858381879600187980118898941890043190785419080031892843189290219005271900586186564718657021911948
Basic Information
VIS ID
TVIS20000883
Fusion event
HPV-NSD2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
AY262282.1
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
1913675/1911948 (Hg38)
End
1913675/1911948 (Hg38)
Location type
Intronic
Target gene
NSD2
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-615-3p ; hsa-mir-423-3p ; hsa-mir-339-5p ; hsa-mir-324-5p ; hsa-mir-92a-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-520g-3p ; hsa-mir-520h ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-4262 ; hsa-mir-3674 ; hsa-mir-3973 ; hsa-mir-3591-5p ; hsa-mir-548at-5p ; hsa-mir-5681b ; hsa-mir-6832-5p ; hsa-mir-4423-3p ; hsa-mir-5582-5p ; hsa-mir-6826-5p ; hsa-mir-503-3p ; hsa-mir-95-3p ; hsa-mir-4732-5p ; hsa-mir-4255 ; hsa-mir-142-3p ; hsa-mir-4256 ; hsa-mir-4762-3p ; hsa-mir-4775 ; hsa-mir-3622a-5p ; hsa-mir-1206 ; hsa-mir-3657 ; hsa-mir-4467 ; hsa-mir-4669 ; hsa-mir-5589-5p ; hsa-mir-6770-3p
Nearest miRNA
hsa-mir-571/Upstream/1561696; hsa-mir-12113/Downstream/74436;
Nearest TSS
ENST00000502981/Upstream/11298; ENST00000511904/Downstream/6484;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/39689, chr4-CpG: 24/Downstream/66905
Nearest cancer related gene
NSD2(OG, No orient, 0)
Upstream sequence
tttttgagagttttaatcatgagtggtgttgaattttgtcaaatggtttttctgcatctattgggaccatgttttgttttgtttttcttttttttttttt
Downstream sequence
TTGTGTGTGCTGTTACAGGTTTTCTTTATTATAAAAATGCTATAACATACCTGTATTCATTTTCATTACTAAGAAAAGTTCTTACAAAGTTTTAAAGTAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate