Basic Information
VIS ID
TVIS20000885
Fusion event
HPV-TGFBI integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
AY262282.1
Host Sequence
Chromosome
chr5
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
135388851/136053162 (Hg38)
End
135388851/136053162 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA5C
Target gene
TGFBI
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-9-5p ; hsa-mir-30a-5p ; hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-675-5p ; hsa-mir-6070 ; hsa-mir-7977 ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-6787-3p ; hsa-mir-4267 ; hsa-mir-5690 ; hsa-mir-5588-3p ; hsa-mir-6854-5p ; hsa-mir-629-3p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-3925-3p ; hsa-mir-766-3p ; hsa-mir-1322 ; hsa-mir-580-5p
Nearest miRNA
hsa-mir-10397/Upstream/250087; hsa-mir-103a-1/Downstream/1594410;
Nearest TSS
ENST00000502646/Upstream/3646; ENST00000509485/Downstream/781;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/23815, chr5-CpG: 18/Downstream/26218
Nearest cancer related gene
TGFBI(TSG, No orient, 0)
Upstream sequence
CACTAGGATGCTATGGAGTAGGAGGAGCTCGGGAGCTTCCACAAACTGAGAAAGCACCTGCAGAAagggaagcaatggagcacactaattaaggatacgc
Downstream sequence
TCTCTTCTGCCATCCTTTGTGGCGGGGGAGGGGAAATTCAGAGATCTTTGGGCGACTTCCCTGCCTGGACCCAGCTCACAGCTTCTCGGCCACTGCAAAT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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