Basic Information
VIS ID
TVIS20000889
Fusion event
HPV-IKBKB integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
AY262282.1
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
42152198/42294680 (Hg38)
End
42152198/42294680 (Hg38)
Location type
Intronic
Target gene
IKBKB
miRNAs that regulate target gene
hsa-mir-199a-5p ; hsa-mir-218-5p ; hsa-mir-200c-3p ; hsa-mir-335-5p ; hsa-mir-151a-3p ; hsa-mir-503-5p ; hsa-mir-451a ; hsa-mir-148a-3p ; hsa-mir-200b-3p ; hsa-mir-497-5p
Nearest miRNA
hsa-mir-124-1/Upstream/634172; hsa-mir-10400/Downstream/601517;
Nearest TSS
ENST00000518652/Upstream/22597; ENST00000522545/Downstream/19345;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/23057, chr8-CpG: 36/Downstream/43662
Upstream sequence
ATAAAATGTATCATACCAAGTAGCAATTCACAAATGTCATTATTTTGTTTAAACAGGAGCCTAATTTCTCTAAATGAATTTTAAAACCAGTGAGTATATA
Downstream sequence
AGGATACGTTGACATTACATCAGTTTTATTTGACTCGAATGAGCACCCAGTGCTGGCCCAAGGGATCCCCTGCACATGGCCCGCATGAGTCTCTTCTCTG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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