Basic Information
VIS ID
TVIS20000906
Fusion event
HPV-CLSTN2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
AY262282.1
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
140014154/140295312 (Hg38)
End
140014154/140295312 (Hg38)
Location type
Intronic
Target gene
CLSTN2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-3180-5p ; hsa-mir-3607-3p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-10b-3p ; hsa-mir-1343-5p ; hsa-mir-145-3p ; hsa-mir-1914-5p ; hsa-mir-3150a-3p ; hsa-mir-3175 ; hsa-mir-4434 ; hsa-mir-4516 ; hsa-mir-5703 ; hsa-mir-6763-5p ; hsa-mir-6825-5p ; hsa-mir-6878-5p ; hsa-mir-7152-5p ; hsa-mir-939-5p
Nearest miRNA
hsa-let-7g/Upstream/5857406; hsa-mir-1224/Downstream/11270564;
Nearest TSS
ENST00000440867/Upstream/360125; ENST00000286349/Downstream/159419;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/359039, chr3-CpG: 37/Downstream/387305
Upstream sequence
CTTTAAGGAAGCAGCCACTTCCTCACTGTACTGGTAGGGCTGCCATTCACATCATATGCCCAGAAGGCACTTAGAGCTCAGTAATCTCATGGCCATGGCC
Downstream sequence
CAGCTTGTATAGTGGGTATTTCAGCCTTTTATCCACCACATAAACTATTTCCCTTGGTTTTAAAATGCACCTTTCAATCTGTTTGTCATAGTTTTTCCTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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