Basic Information
VIS ID
TVIS20000910
Fusion event
HPV-chr1:p36.13 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
p36.13
Reference genome
GRCh37/hg19
Start
18490679/18164185 (Hg38)
End
18490679/18164185 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
IGSF21 ; IGSF21-AS1
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-12136/Upstream/886210; hsa-mir-101-1/Downstream/719017;
Nearest TSS
ENST00000473358/Upstream/56439; ENST00000412684/Downstream/15161;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/53006, chr1-CpG: 18/Downstream/201195
Upstream sequence
AAGGAATGGCCACTGAAGATTAATTGCTGTGGCAGAAAGGACAGTGTTATGGCATTCTGTTAGAATTTTTATTCAGCATTTGTAATTGGATTTTTTTTTG
Downstream sequence
AATTGTTACTTTTGTGTGTGTGTGGGGAGGGAGTTGTTGTCGACCATTTATATCACCTTAATGAGTGCACAAGAGTCGGGAAGAGACAAAAAGAACATGA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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