Basic Information
VIS ID
TVIS20000914
Fusion event
HPV-NES integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
156640162/156670370 (Hg38)
End
156640162/156670370 (Hg38)
Location type
Intronic
Target gene
NES
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-125b-5p ; hsa-mir-432-5p ; hsa-mir-487b-5p
Nearest miRNA
hsa-mir-101-1/Upstream/249941; hsa-mir-1182/Downstream/265761;
Nearest TSS
ENST00000473358/Upstream/8946; ENST00000524343/Downstream/7027;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/12586, chr1-CpG: 108/Downstream/6130
Upstream sequence
TATTGATTTGAAGTGCTTAAAAAATGGCAAGGCTAGAGTATTGGGAAGTAAATTCTTAAGTTGCTAAAAACATTGGCAAGGGATGAGATGGATGGGTGGA
Downstream sequence
GGTCTGTTAGCCAGGCACAAAAGGCTCACTCCCCAGGAAATGATTGAGGAACTCCAGAAACGTTGCATCCACCTGGAGTACCCTCTGTTGGCAGAATATG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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