Basic Information
VIS ID
TVIS20000923
Fusion event
HPV-PAX2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
102538753/100778996 (Hg38)
End
102538753/100778996 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
PAX2
miRNAs that regulate target gene
hsa-mir-423-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1237-5p ; hsa-mir-6729-5p ; hsa-mir-4649-5p ; hsa-mir-744-5p ; hsa-mir-6775-5p ; hsa-mir-2277-5p ; hsa-mir-5090 ; hsa-mir-6805-5p ; hsa-mir-486-3p ; hsa-mir-6721-5p ; hsa-mir-7106-5p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-766-5p ; hsa-mir-3148 ; hsa-mir-3184-5p ; hsa-mir-570-3p ; hsa-mir-4441 ; hsa-mir-6754-5p ; hsa-mir-4270 ; hsa-mir-6743-5p ; hsa-mir-4688 ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321
Nearest miRNA
hsa-mir-107/Upstream/1854428; hsa-mir-1307/Downstream/195989;
Nearest TSS
ENST00000439456/Upstream/30146; ENST00000609386/Downstream/133573;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/29107, chr10-CpG: 260/Downstream/47372
Nearest cancer related gene
PAX2(OG, No orient, 0)
Upstream sequence
tgttaatctaatagattttcctttataggctacctggtgcttctgtctcacagctcttaagattatttccttcaccttaactttggataacctgatgaca
Downstream sequence
atgtgcaatgaatttcccaggtgttctttgtgtttcttgtatcgcatgtctaggtctctagcaaggccggggaagttttcttcgattattctcccaaata
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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