Basic Information
VIS ID
TVIS20000932
Fusion event
HPV-PTPRO integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr12
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
15748448/15595514 (Hg38)
End
15748448/15595514 (Hg38)
Location type
Intronic
Target gene
PTPRO
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-26b-5p ; hsa-mir-20a-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/2679596; hsa-let-7i/Downstream/2077785;
Nearest TSS
ENST00000382841/Upstream/293; ENST00000544015/Downstream/36248;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/272547, chr12-CpG: 104/Downstream/193270
Upstream sequence
CATTTATGTTCTCAATTTTTTTAAAGTCCTTGCTCTTGTTCTATATCAGGAATACTCAGGAGATGAAAAATAGCACAGAACCTTTTTCCCTGTGACAGAC
Downstream sequence
GATGAGATGCTAATGGAGCCAGCCTCACACTAGGTGAAGGTCCATTGCATAGGGTTATGGGTTATGATGGGATTTCAGAGTGAATATTCTTCTTAAAAAT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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