Basic Information
VIS ID
TVIS20000966
Fusion event
HPV-CBWD2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
114224273/113466696 (Hg38)
End
114224273/113466696 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2B
Target gene
CBWD2
miRNAs that regulate target gene
hsa-mir-375
Nearest miRNA
hsa-mir-1285-2/Upstream/1695562; hsa-mir-10b/Downstream/116263;
Nearest TSS
ENST00000437798/Upstream/22934; ENST00000479583/Downstream/1889;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/28710, chr2-CpG: 103/Downstream/32502
Upstream sequence
ggagagaagggacagttcatctacaaagggaaccccatcaagctaacagcaaacctttcagtagaaaccctacaagccagaagagattagcggcctatat
Downstream sequence
TGGGTCCTGAATCTTACATTAAATATTCTCTCAAATTCCTTGAGGCATAGCAACTTGAGCTTACCAGTTTAGAAACTGGAGATTTGggctgggcgcggtg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate