Basic Information
VIS ID
TVIS20000973
Fusion event
HPV-SPAG16 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr2
Cytoband
q34
Reference genome
GRCh37/hg19
Start
215125185/214260461 (Hg38)
End
215125185/214260461 (Hg38)
Location type
Intronic
Target gene
SPAG16
miRNAs that regulate target gene
hsa-mir-4713-5p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-2116-3p ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-1224-3p ; hsa-mir-6507-3p ; hsa-mir-6828-5p ; hsa-mir-651-3p ; hsa-mir-3662
Nearest miRNA
hsa-mir-10b/Upstream/502302; hsa-mir-1244-1/Downstream/3640052;
Nearest TSS
ENST00000437798/Upstream/336598; ENST00000477752/Downstream/150604;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/975759, chr2-CpG: 110/Downstream/548810
Upstream sequence
AGTTTTCAAGAAAAAATGTTTTAACATCCTTAACCATCTTGGTTAAGGATATTTAAAAAGTCAACATTGTTTACAGTCGTTCCGCATTCCCCTAACTTTA
Downstream sequence
CTACTGTGTTATAGATGCCAAACATTAGAGAAAATAATTTAGTCCTTGGTTCATCTGACTACACTGGCATCCATTAAAAGTCTATTATTTCTTTGGTTAT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate