Basic Information
VIS ID
TVIS20000976
Fusion event
HPV-USP25 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
17127261/15754942 (Hg38)
End
17127261/15754942 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA21A
Target gene
USP25
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-101-3p ; hsa-mir-27a-3p ; hsa-mir-454-5p ; hsa-mir-200c-3p ; hsa-mir-297 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-4666a-5p ; hsa-mir-27b-3p ; hsa-mir-513a-5p ; hsa-mir-6832-5p ; hsa-mir-16-1-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-411-5p ; hsa-mir-3123 ; hsa-mir-3925-5p ; hsa-mir-144-3p
Nearest miRNA
hsa-mir-10396a/Upstream/2030668; hsa-let-7c/Downstream/784147;
Nearest TSS
ENST00000624081/Upstream/24917; ENST00000464435/Downstream/18314;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/24458, chr21-CpG: 138/Downstream/1757546
Upstream sequence
TTCTTTGCTTTCTGGCTATTTAGAGACTGGTTTGGACTTACAAACATGAAGGATGTGTTATGTACTTGAAATTCTTGGACAGTGAGTATTAGAGGTTTCT
Downstream sequence
TATGGTAAGAGAACATGAGCTAGAGCAGTGTAGTGTTAGCAGGTAGATGCAGAGGTTTTTGCAAAATCAGGTGTGTGTGTGATTACTCACTTTAAAGACA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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