Basic Information
VIS ID
TVIS20000985
Fusion event
HPV-FHIT integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
End
60585847/60600114 (Hg38)
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-let-7g/Upstream/4747520; hsa-mir-12124/Downstream/17691;
Nearest cancer related gene
FHIT(TSG, No orient, 0)
Upstream sequence
CTATATGACATGTAACAAGGAAAAATAACAATAGATACAACTGGACAAACTGTAGGAGACAGATTCTCTCTGGggaacaaagactgagaaaaaccctctg
Downstream sequence
GCCCAGAAGGCACTTAGAGCTCAGTAATCTCATGGCCATGGCCTTCCCAATATCCACAGATCCATCCTGCTAAAGGCACCAATGATCAGCTCTTCTCTGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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