Basic Information
VIS ID
TVIS20001008
Fusion event
HPV-ZNF292 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr6
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
87896891/87187173 (Hg38)
End
87896891/87187173 (Hg38)
Location type
Intronic
Target gene
ZNF292
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-196a-3p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-3925-5p ; hsa-mir-3120-3p ; hsa-mir-32-3p ; hsa-mir-1273g-3p ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-508-5p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-mir-6873-3p ; hsa-mir-4795-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-3675-3p ; hsa-mir-7151-5p ; hsa-mir-5003-3p
Nearest miRNA
hsa-mir-10398/Upstream/8647864; hsa-mir-1202/Downstream/3125569;
Nearest TSS
ENST00000381078/Upstream/31552; ENST00000485016/Downstream/26541;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/31114, chr6-CpG: 30/Downstream/135266
Nearest cancer related gene
ZNF292(TSG, No orient, 0)
Upstream sequence
CAGAAATAAGTATCATCACTTTCTATCACAACAAAGACTAGCTTGGCCTTTATAGAATATAATCTTTCTATGTATTTGTTTTCAGTATGTTGTAAGAATA
Downstream sequence
TTGTCAGTCTTCTCTGATTTAAATGTATATTAAGTACTATTAATTATGGGTCCAGGTCAATCATGATAAATATCAGTAAAGTTTAAAAGAAAATCTTGTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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