Basic Information
VIS ID
TVIS20001013
Fusion event
HPV-PDE10A integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr6
Cytoband
q27
Reference genome
GRCh37/hg19
Start
166241837/165828349 (Hg38)
End
166241837/165828349 (Hg38)
Location type
Intronic
Target gene
PDE10A
miRNAs that regulate target gene
hsa-mir-1287-3p ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-511-3p ; hsa-mir-5011-5p ; hsa-mir-7151-5p ; hsa-mir-5681b ; hsa-mir-5579-5p ; hsa-mir-33a-3p
Nearest miRNA
hsa-mir-10398/Upstream/7063596; hsa-mir-1913/Downstream/681005;
Nearest TSS
ENST00000381078/Upstream/74160; ENST00000629776/Downstream/158147;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/961, chr6-CpG: 29/Downstream/25672
Upstream sequence
TCCCTCACCACACTGAATGGAGGAGTATTATGTTCTTCCATGAAGTTAGAATTTAGAGCAACATCTTGCTAAATAGAAGCTATATCAATGTAAACTGTCA
Downstream sequence
ATTTGAGAATAAGCTAGGTCTGAAAAATTAGTTGTATTAGCTAGGGGTGTTGGGACAGAAGTGTAAGTAAGTTTAAACAAAAGTGAAATGCAGGTAATGa
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate