Basic Information
VIS ID
TVIS20001028
Fusion event
HPV-FAM135B integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr8
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
139247656/138235413 (Hg38)
End
139247656/138235413 (Hg38)
Location type
Intronic
Target gene
FAM135B
miRNAs that regulate target gene
hsa-mir-6823-3p ; hsa-mir-2114-3p ; hsa-mir-615-3p ; hsa-mir-361-3p
Nearest miRNA
hsa-mir-1204/Upstream/3430468; hsa-mir-10400/Downstream/2497151;
Nearest TSS
ENST00000518652/Upstream/83009; ENST00000518354/Downstream/190102;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/2777314, chr8-CpG: 119/Downstream/261139
Upstream sequence
gaacagacaaaacccttgctttctattgatgacagagccaatattttggggtgaagaATTTGGAGAATAGTTGTTTTAAAATAACTCTGGCTTAAAGGAA
Downstream sequence
CCTGTCTAGAGACAACATAATGTCATGTTTAATGATAATTATGCATGTCTGTGTCTTACGTATGTGACTACATCCTCATGAAAAGAATATGAGGGTGTTC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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