Basic Information
VIS ID
TVIS20001041
Fusion event
HPV-DNASE1L1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
153636009/154407673 (Hg38)
End
153636009/154407673 (Hg38)
Location type
Intronic
Fragile sites / regions
FRAXE ; FRAXF
Target gene
DNASE1L1
miRNAs that regulate target gene
hsa-mir-484
Nearest miRNA
hsa-let-7f-2/Upstream/387684; hsa-mir-1184-1/Downstream/42647;
Nearest TSS
ENST00000429181/Upstream/2055; ENST00000614595/Downstream/1603;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/8690, chrX-CpG: 102/Downstream/3725
Upstream sequence
TTAATTTTATCACCTTATATCAATatagatagatgatagataaatagataatagatacatagaaaaataagagagagagataTACCAATTACATACATCT
Downstream sequence
caacctctgccttccgggttcaagtgattctcctgcctcagcctcctgagtagttggggctacaggcgtgagccaccgcgcccagccccccccctttttt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate