Basic Information
VIS ID
TVIS20001064
Fusion event
HPV-KCNT2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
196256684/196287554 (Hg38)
End
196256684/196287554 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1K
Target gene
KCNT2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-4775 ; hsa-mir-500a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/3150971; hsa-mir-1182/Downstream/294859;
Nearest TSS
ENST00000473358/Upstream/226481; ENST00000496761/Downstream/140653;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3165460, chr1-CpG: 24/Downstream/321024
Upstream sequence
TTAGGTTTATCAGTAAGCTAGGGGAAACAAATTACATACATTGTATAGGTAGTAACCTATGAAAAAAGTGGAGATTAGGTAAAAATTATTAAGTGAAATT
Downstream sequence
ATTCATGTGCTTTCAGTTTCATCTTTCTCCTGGGAAAGCCCCAAAACAGGCCTCTGGAAAACCAATTTCATACATGTACAAAATGGCATCTGCTCTCAAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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