Basic Information
VIS ID
TVIS20001077
Fusion event
HPV-NEBL integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr10
Cytoband
p12.31
Reference genome
GRCh37/hg19
Start
21214676/20925747 (Hg38)
End
21214676/20925747 (Hg38)
Location type
Intronic
Target gene
NEBL
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-7856-5p ; hsa-mir-4477b ; hsa-mir-4684-5p ; hsa-mir-6892-5p ; hsa-mir-942-5p ; hsa-mir-7845-5p ; hsa-mir-4475 ; hsa-mir-6507-3p ; hsa-mir-6883-3p ; hsa-mir-3156-3p ; hsa-mir-324-5p ; hsa-mir-3162-3p ; hsa-mir-4301 ; hsa-mir-140-3p
Nearest miRNA
hsa-mir-1265/Upstream/373701; hsa-mir-107/Downstream/570815;
Nearest TSS
ENST00000439456/Upstream/26056; ENST00000417845/Downstream/220812;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1107730, chr10-CpG: 149/Downstream/247452
Upstream sequence
tatcaccatcataagttttgctggttctagaatttcatataaatacaattaaaggcatacattcttttatgtgtgacttcttttgctcaacatgtctact
Downstream sequence
aggatgatcttggttgttgtgtatattatcagttattttattgctattactttttatggttgagtgtattccattgtatgaatatataaacagttctcct
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate