Basic Information
VIS ID
TVIS20001096
Fusion event
HPV-PRXL2A integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr10
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
82171799/80412043 (Hg38)
End
82171799/80412043 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
PRXL2A
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-3130-3p ; hsa-mir-7108-3p ; hsa-mir-6793-3p ; hsa-mir-4733-3p ; hsa-mir-4274 ; hsa-mir-642a-5p ; hsa-mir-6866-5p ; hsa-mir-877-5p ; hsa-mir-4469 ; hsa-mir-4778-3p ; hsa-mir-877-3p ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-500b-3p ; hsa-mir-2114-5p ; hsa-mir-4482-5p ; hsa-mir-3130-5p ; hsa-mir-5089-5p ; hsa-mir-6878-3p ; hsa-mir-1178-3p ; hsa-mir-5095 ; hsa-mir-6744-3p ; hsa-mir-4757-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-150-5p ; hsa-mir-212-5p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-6504-3p ; hsa-mir-512-3p ; hsa-mir-6813-3p ; hsa-mir-552-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p
Nearest miRNA
hsa-mir-1265/Upstream/4859490; hsa-mir-107/Downstream/5852651;
Nearest TSS
ENST00000439456/Upstream/3549; ENST00000372187/Downstream/1776;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2882, chr10-CpG: 119/Downstream/41757
Upstream sequence
TCTAAGAAGAATTTTTTTCACCTTCAATACATGAGAATCATTATAGGCCCAACTTCCACTCTTATCACTGGAAGTTCTATAATGGACATTAGCTCCCAGA
Downstream sequence
AAAAAATTGCAGCACTATTTAATAAAGATATTATATCTAAAACTGTAAGGGATGGTAATCAAAATAACGTGCCTTCTAAAAAATCCAAATAAATATAAAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate