Basic Information
VIS ID
TVIS20001098
Fusion event
HPV-PLCE1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr10
Cytoband
q23.33
Reference genome
GRCh37/hg19
Start
96064794/94305037 (Hg38)
End
96064794/94305037 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
PLCE1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-6715b-5p ; hsa-mir-4269 ; hsa-mir-5582-5p ; hsa-mir-6768-5p ; hsa-mir-8485 ; hsa-mir-1200 ; hsa-mir-3188 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-2467-5p ; hsa-mir-3975 ; hsa-mir-4649-3p ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-4789-3p ; hsa-mir-6807-5p ; hsa-mir-4653-3p ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-4438 ; hsa-mir-665 ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-7847-3p ; hsa-mir-6880-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-6134 ; hsa-mir-1827 ; hsa-mir-3192-5p ; hsa-mir-4768-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-7851-3p ; hsa-mir-34b-3p ; hsa-mir-490-3p ; hsa-mir-3611 ; hsa-mir-6126 ; hsa-mir-4493 ; hsa-mir-605-3p ; hsa-mir-4277 ; hsa-mir-584-3p ; hsa-mir-5000-5p ; hsa-mir-328-3p ; hsa-mir-145-3p ; hsa-mir-4307
Nearest miRNA
hsa-mir-107/Upstream/4712210; hsa-mir-1287/Downstream/1759278;
Nearest TSS
ENST00000439456/Upstream/17559; ENST00000464214/Downstream/10290;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/310593, chr10-CpG: 39/Downstream/57746
Nearest cancer related gene
PLCE1(TSG, No orient, 0)
Upstream sequence
tcttgatgaaagagatattttagaacacctcatctggtcattgtgttttagatgcaatgaaaggaacagaaggagataaggccaattaggaagttactgc
Downstream sequence
agtaactcaggcaagataatggcctgaacacagTGAAACTGAAAAGAAAGGAATATGGGAAAAAAGGATTTCATGAAAAAAGGATCTTCACAGATTGTTC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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