Basic Information
VIS ID
TVIS20001100
Fusion event
HPV-TRUB1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr10
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
116704367/114944608 (Hg38)
End
116704367/114944608 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
TRUB1
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-153-3p ; hsa-mir-455-5p ; hsa-mir-4729 ; hsa-mir-5700 ; hsa-mir-194-5p ; hsa-mir-4426 ; hsa-mir-4451 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-4775 ; hsa-mir-510-3p ; hsa-mir-548g-3p ; hsa-mir-4738-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-202-5p ; hsa-mir-6845-3p ; hsa-mir-5582-3p ; hsa-mir-2115-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-8067 ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-3922-5p ; hsa-mir-15a-3p ; hsa-mir-4753-5p ; hsa-mir-4446-5p ; hsa-mir-379-5p ; hsa-mir-3529-5p ; hsa-mir-4650-3p ; hsa-mir-323a-3p ; hsa-mir-590-3p ; hsa-mir-212-3p ; hsa-mir-132-3p
Nearest miRNA
hsa-mir-107/Upstream/770429; hsa-mir-202/Downstream/1882880;
Nearest TSS
ENST00000439456/Upstream/6222; ENST00000433085/Downstream/50049;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/5991, chr10-CpG: 183/Downstream/147894
Upstream sequence
acagaaggagataaggccaattaggaagttactgcagtaactcaggcaagataatggcctgaacacagTGAAACTGAAAAGAAAGGAATATGGGAAAAAA
Downstream sequence
GGATTTCATGAAAAAAGGATCTTCACAGATTGTTCACTGAATCCCTCATCTCTTGTTTCAAAAAAAAAAAAAAGTCATATGTGTTAATTCTTTTATTACC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate