Basic Information
VIS ID
TVIS20001105
Fusion event
HPV-SWAP70 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
9742338/9720791 (Hg38)
End
9742338/9720791 (Hg38)
Location type
Intronic
Target gene
SWAP70
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-145-5p ; hsa-mir-23c ; hsa-mir-23a-3p ; hsa-mir-23b-3p ; hsa-mir-130a-5p ; hsa-mir-4637 ; hsa-mir-4445-5p ; hsa-mir-186-3p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a
Nearest miRNA
hsa-mir-210/Upstream/630412; hsa-let-7a-2/Downstream/787479;
Nearest TSS
ENST00000527297/Upstream/725; ENST00000534562/Downstream/6104;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/56288, chr11-CpG: 72/Downstream/37426
Nearest cancer related gene
SWAP70(OG, No orient, 0)
Upstream sequence
TATACAAAGCAATGCTTAGGGATATACGTGCTATATTTCTTTTAGTTACTGTGACTATCCATAAGGACAATATCTTTTTTACATTCAAGAAGCTGGATAT
Downstream sequence
CGGAGTTTTAGAAGGTTATCTTCTAGGATTTTTGTATtgtgttgtgtcctccaagaagacacaacacagaattatatttgcaagaggtttatttggaaaa
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate