Basic Information
VIS ID
TVIS20001115
Fusion event
HPV-PPME1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr11
Cytoband
q13.4
Reference genome
GRCh37/hg19
Start
73907175/74196130 (Hg38)
End
73907175/74196130 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
PPME1
Nearest miRNA
hsa-mir-10392/Upstream/1412538; hsa-let-7a-2/Downstream/203107;
Nearest TSS
ENST00000527297/Upstream/24787; ENST00000535205/Downstream/34655;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/24603, chr11-CpG: 38/Downstream/115253
Upstream sequence
atcaattgaatggttgaacaatatcctatcacaaagagaataaaatatataaatattctacttctttgaacatttactttgctttacattttttcctatt
Downstream sequence
atatgtatgagttgataaacatctttttactcatctttgtttacatttTGAGGAAATTGCTGTATTAATTAAGTAGTTGTATGCAAATGTATTATCGTGC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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