Basic Information
VIS ID
TVIS20001129
Fusion event
HPV-ANO6 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr12
Cytoband
q12
Reference genome
GRCh37/hg19
Start
45766647/45372864 (Hg38)
End
45766647/45372864 (Hg38)
Location type
Intronic
Target gene
ANO6
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-192-5p ; hsa-mir-615-3p ; hsa-mir-182-5p ; hsa-mir-10a-5p ; hsa-let-7a-5p ; hsa-mir-3620-3p ; hsa-mir-218-5p ; hsa-mir-631 ; hsa-mir-3661 ; hsa-mir-500b-3p ; hsa-mir-3908
Nearest miRNA
hsa-mir-1244-3/Upstream/3049005; hsa-let-7i/Downstream/1814948;
Nearest TSS
ENST00000382841/Upstream/37315; ENST00000427628/Downstream/237726;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/155895, chr12-CpG: 72/Downstream/354079
Upstream sequence
tggcatgtgcctgtagtcccagctactcggtaggctgaggcaggaagatcgctagaatccaggaggcagaggttgcagtgagtcgagatcaggccattgc
Downstream sequence
actccagcctgggtgacagagcaagactctgtcttcaaaaaaaaaaaaaaaaagtattgaataattgaatGAATGTTCTGCAATGTAACAGTCCAGTTAG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate