Basic Information
VIS ID
TVIS20001134
Fusion event
HPV-LTA4H integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr12
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
96411603/96017825 (Hg38)
End
96411603/96017825 (Hg38)
Location type
Intronic
Target gene
LTA4H
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-125b-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-let-7i/Upstream/707841; hsa-mir-1178/Downstream/1474084;
Nearest TSS
ENST00000382841/Upstream/2651; ENST00000547346/Downstream/7498;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/21928, chr12-CpG: 41/Downstream/17411
Upstream sequence
TGCGTCCACAAAGTCAAGGGGAAATATTCACCTGTTGTTAACTTAATTTGTATATGAGATGTTAACCAAATGTTGGGGCTAAATTGCAGTAGATGTGTTA
Downstream sequence
CTTATTGTTGTAAGCGCCTAGGGTAATATTTATATCCCTTGAGTTTGGCTGCTTTTTTTAATCAAATCTCTTTTCCCCACTTTTTCATTGTTTCACTCAT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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