Basic Information
VIS ID
TVIS20001136
Fusion event
HPV-TRPV4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr12
Cytoband
q24.11
Reference genome
GRCh37/hg19
Start
110232881/109795076 (Hg38)
End
110232881/109795076 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
TRPV4
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-let-7i/Upstream/958070; hsa-mir-1178/Downstream/38272;
Nearest TSS
ENST00000382841/Upstream/21568; ENST00000446473/Downstream/19720;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/76359, chr12-CpG: 20/Downstream/38461
Upstream sequence
AATTAGGTACAATATTTCTAGTCTTTTAAATAGTCTCTGTTTACAACTATCCCTGGTTGGTATTCCATCTAATTATAAGAAGTTCCAATATTGTCTAACA
Downstream sequence
CACCATTTCCAACTATTCGATTCTAAAGAACAATGTTACTGGAGAGCCACTGAGTACACAAACCTGTTAAATAACTGATTATTAGCAAGACATTATAACT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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