Basic Information
VIS ID
TVIS20001149
Fusion event
HPV-TTC6 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
38101899/37632694 (Hg38)
End
38101899/37632694 (Hg38)
Location type
Intronic
Target gene
TTC6
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-208a/Upstream/680303; hsa-mir-1185-1/Downstream/10128301;
Nearest TSS
ENST00000550708/Upstream/10629; ENST00000554555/Downstream/139689;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/9723, chr14-CpG: 43/Downstream/575255
Upstream sequence
ACTTGGCAGGGTGCTTGGAGATCCTGGCGTTTCCCCACCTGCTGCTCCTGTGTGCAAGAGCTGGGAGGCTGGAAACCTGGGCGAGGGTAGGTCAGGACCT
Downstream sequence
aagtctgctcaagctgcacccccagccgccccttccaccaggtgctctgtcccagagagatgggagttttatctgtaagccatgagtggggctcctgcct
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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