Basic Information
VIS ID
TVIS20001175
Fusion event
HPV-PARN integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr16
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
14634418/14540561 (Hg38)
End
14634418/14540561 (Hg38)
Location type
Intronic
Target gene
PARN
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-377-3p ; hsa-mir-8485 ; hsa-mir-521 ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-376a-2-5p
Nearest miRNA
hsa-mir-1225/Upstream/231190; hsa-mir-11401/Downstream/360947;
Nearest TSS
ENST00000527434/Upstream/38872; ENST00000570219/Downstream/24514;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/237343, chr16-CpG: 55/Downstream/89184
Upstream sequence
ttcctttttttttttcagatggagtctggctctgtcacccaggctggagtgcagtggcacgatctcggctcactgcaacctccgcctcctgtgttcaagc
Downstream sequence
ATTAGATTTTCTGAAAATGTTATTAAAGTAGTTTAAGCATGGTATGTGATATGGAAGGAAGGTCTGGATCACAAAATAGGTGCCAgccaggcacggtggc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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