Basic Information
VIS ID
TVIS20001186
Fusion event
HPV-COX10 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
13976847/14073530 (Hg38)
End
13976847/14073530 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA17A
Target gene
COX10
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-98-5p ; hsa-mir-19b-3p ; hsa-let-7e-5p ; hsa-mir-19a-3p ; hsa-mir-130a-3p ; hsa-mir-301a-3p ; hsa-mir-432-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-4764-5p ; hsa-mir-8062 ; hsa-mir-3942-3p ; hsa-mir-5100 ; hsa-mir-509-3p ; hsa-mir-205-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-6819-5p ; hsa-mir-6737-5p ; hsa-mir-6812-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-101-3p ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-6073 ; hsa-mir-6747-5p ; hsa-mir-608 ; hsa-mir-4651 ; hsa-mir-4664-5p ; hsa-mir-342-5p ; hsa-mir-6848-5p ; hsa-mir-6846-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-1237-5p ; hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-7114-3p ; hsa-mir-1180-5p ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-6890-5p ; hsa-mir-4257 ; hsa-mir-508-5p ; hsa-mir-144-3p ; hsa-mir-4506
Nearest miRNA
hsa-mir-1253/Upstream/529884; hsa-mir-10226/Downstream/1178097;
Nearest TSS
ENST00000595228/Upstream/3926; ENST00000458492/Downstream/136958;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/3762, chr17-CpG: 29/Downstream/133350
Upstream sequence
AGTGCAGCAACAAGGCGCCTTTAGCCCCCTTGTCGTTTTTGGCCCCAAAAGTGCCACAGTTACACAGGGTGGCCCTGGAGCAAAGTGAGTGCTAATGCGC
Downstream sequence
GATCAGAAATTATCCTATAATTACATTTGCTCAGGGACAATATTTAATGTTCAGAAAGAGGGAACATGGATACCTTAAGGTGGCATACATAGCAAGAATA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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