Basic Information
VIS ID
TVIS20001192
Fusion event
HPV-JUP integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr17
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
39911034/41754782 (Hg38)
End
39911034/41754782 (Hg38)
Location type
Intronic
Target gene
JUP
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-1-3p ; hsa-mir-30a-5p ; hsa-mir-615-3p ; hsa-mir-30c-5p
Nearest miRNA
hsa-mir-1180/Upstream/237565; hsa-mir-10226/Downstream/739991;
Nearest TSS
ENST00000595228/Upstream/20138; ENST00000429461/Downstream/8295;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/19545, chr17-CpG: 22/Downstream/2682
Nearest cancer related gene
JUP(OG, No orient, 0)
Upstream sequence
AAAAGAGATTATATTCAAGGATGCTCTATTACTTTGAATAGGCGAAACATTCCAGGCTGATGGGAATTCATACCTGTCAACAGCTGTGAATTAGCATTTC
Downstream sequence
ACCAGAGGGGTCAGCCAAGAGCACTTCTCGGGGTCAGCTAGGGCAGCTGTGTGGGTGGGACAGGGGTGTGAGGAAGCTGTCCCCAGAGCTCCCTGGGGAG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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