Basic Information
VIS ID
TVIS20001219
Fusion event
HPV-EIF2AK2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr2
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
37328031/37100888 (Hg38)
End
37328031/37100888 (Hg38)
Location type
Intronic
Target gene
EIF2AK2
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-124-3p ; hsa-mir-877-5p ; hsa-mir-15b-5p ; hsa-mir-4769-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-6867-5p ; hsa-mir-574-5p ; hsa-mir-202-5p ; hsa-mir-7158-5p ; hsa-mir-6832-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-5196-3p ; hsa-mir-665 ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-298 ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4649-3p ; hsa-mir-3664-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-4695-5p ; hsa-mir-510-5p ; hsa-mir-34b-3p ; hsa-mir-495-5p ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-4762-5p ; hsa-mir-5586-5p ; hsa-mir-3606-3p ; hsa-mir-4282 ; hsa-mir-4698 ; hsa-mir-513a-3p ; hsa-mir-513c-3p ; hsa-mir-8063
Nearest miRNA
hsa-mir-1301/Upstream/1629402; hsa-mir-10b/Downstream/10276787;
Nearest TSS
ENST00000437798/Upstream/12524; ENST00000470216/Downstream/8612;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/16138, chr2-CpG: 31/Downstream/55870
Upstream sequence
cacctgtgggagactGGTTTGGGGCTGAACAATATGAGAAAGGGGCTTCGCAGAGACTGATCTCCTTGCCTGCTTGGAAGTTCCTGGCTCTCTGAAAGTG
Downstream sequence
GGTAAAAGTGTGAGACAAAGTACCCCTCAAATACATGTGGCTCTTGGGGTTCATCTGACTGAGACTTGTATTTACTTGaatggcatcagaatcctgctac
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate