Basic Information
VIS ID
TVIS20001233
Fusion event
HPV-LOC105373667 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr2
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
147038897/146281329 (Hg38)
End
147038897/146281329 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2K
Target gene
LOC105373667
Nearest miRNA
hsa-mir-128-1/Upstream/5694644; hsa-mir-10b/Downstream/3048949;
Nearest TSS
ENST00000437798/Upstream/366239; ENST00000450667/Downstream/556420;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1756841, chr2-CpG: 49/Downstream/305904
Upstream sequence
tgcctggctaattgttttgtatttttagtagagatagggtttcgccatgttggccaggcttgtcttgaactcctgacctcaagtgatccgcccacctcgg
Downstream sequence
tgtgaacattATATAAATCACCACATTGTTAAAAAAACTTATATATGATTCACCAACAGAGTACTGAAATCCCAATTTCATAGTATCTTCACCAGCACTG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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