Basic Information
VIS ID
TVIS20001238
Fusion event
HPV-FLACC1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
202179603/201314880 (Hg38)
End
202179603/201314880 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2I
Target gene
FLACC1
miRNAs that regulate target gene
hsa-mir-1236-3p
Nearest miRNA
hsa-mir-10b/Upstream/12181769; hsa-mir-1244-1/Downstream/5468354;
Nearest TSS
ENST00000437798/Upstream/5631; ENST00000488196/Downstream/33421;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/195894, chr2-CpG: 110/Downstream/136250
Upstream sequence
ATAATACAATGTTCCACATAACTTTATAAGAACCTCTGCAACAGCTTTTGTGTATATCaaattaaaatttactatataataaaattatGTAGTAATAATT
Downstream sequence
tcagcctccttaaacaaaacaattatcagccaagaattttgtaccaagcaaaaccaagcttcataaatgaaggaaagatacagtctttttcaggcaaaca
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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