Basic Information
VIS ID
TVIS20001248
Fusion event
HPV-SYNDIG1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr20
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
24554181/24573545 (Hg38)
End
24554181/24573545 (Hg38)
Location type
Intronic
Target gene
SYNDIG1
miRNAs that regulate target gene
hsa-mir-17-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/6102854; hsa-mir-1-1/Downstream/1634641;
Nearest TSS
ENST00000382410/Upstream/71200; ENST00000482637/Downstream/11357;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/102144, chr20-CpG: 18/Downstream/344773
Upstream sequence
GGACTATCACAACACCTGTCCAGTTGGCCTCTCTGTCTACTCTTTCCACGCCTAGGTTATAAATTACTCAGTTGTAGCTATTATACCTCATAACTTTCTG
Downstream sequence
AGTATCATCGCCAGCTTACACTGATGGCCTGCTGCGCCCTGGTCACTTTGACCTGAATCACGTAGTGATCTTTCACACCAAGTCCTGGAAAGCTTTGGCC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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