Basic Information
VIS ID
TVIS20001258
Fusion event
HPV-ITPR1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr3
Cytoband
p26.1
Reference genome
GRCh37/hg19
Start
4775002/4733318 (Hg38)
End
4775002/4733318 (Hg38)
Location type
Intronic
Target gene
ITPR1
miRNAs that regulate target gene
hsa-mir-424-5p ; hsa-mir-335-5p ; hsa-mir-340-5p ; hsa-mir-128-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-92a-3p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-4328 ; hsa-mir-4803 ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-494-3p ; hsa-mir-34c-5p ; hsa-mir-34b-3p ; hsa-mir-449a ; hsa-mir-448 ; hsa-mir-3163
Nearest miRNA
hsa-let-7g/Downstream/516859;
Nearest TSS
ENST00000440867/Upstream/8941; ENST00000479831/Downstream/18272;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/239635, chr3-CpG: 67/Downstream/134960
Upstream sequence
AACCTGTTAGTTTCTTAGTCATATTCTTTTATTATTATGTTTGTATTCACGGTTCAAAAGATGAAAAATGCAGAGTTTACAGCAGTGCCTGACGGAGAGA
Downstream sequence
AATTTGTGTTGCAGGTGTATTTTTTAGCAACTTGTTTTGTCTTTGGTCTACCATCAAATTGATGCCTAAACATATTTTCCTGCAAACTAGCATTTCCCTG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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