Basic Information
VIS ID
TVIS20001259
Fusion event
HPV-ZNF385D integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr3
Cytoband
p24.3
Reference genome
GRCh37/hg19
Start
21800912/21759420 (Hg38)
End
21800912/21759420 (Hg38)
Location type
Intronic
Target gene
ZNF385D
miRNAs that regulate target gene
hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6868-3p ; hsa-mir-627-3p ; hsa-mir-6734-3p ; hsa-mir-3667-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-2355-5p ; hsa-mir-3124-3p ; hsa-mir-5088-3p
Nearest miRNA
hsa-mir-12127/Upstream/1621779; hsa-let-7g/Downstream/3905453;
Nearest TSS
ENST00000440867/Upstream/7985; ENST00000448980/Downstream/18356;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1572956, chr3-CpG: 86/Downstream/612581
Upstream sequence
cacctgaattctgtcagacattcaaagaattggtaccaatcctatcgacattattccacaaaatagagaaagaagacatcctccctaaatcattctatga
Downstream sequence
CCATATTGGATGAGATCTCCCATTCAAGGAAAAAGGCTTAAATTTTATTTGACAGACAGTGTAGGAAGTGTTTGCTGAATGAATACATAAATGTACTTCC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate