Basic Information
VIS ID
TVIS20001281
Fusion event
HPV-ARAP2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
36012473/36010851 (Hg38)
End
36012473/36010851 (Hg38)
Location type
Intronic
Target gene
ARAP2
miRNAs that regulate target gene
hsa-mir-101-3p ; hsa-mir-26b-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-4703-5p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-3144-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-582-5p ; hsa-mir-6847-3p ; hsa-mir-5186 ; hsa-mir-767-3p ; hsa-mir-4666a-3p ; hsa-mir-1255b-2-3p ; hsa-mir-338-5p ; hsa-mir-300 ; hsa-mir-381-3p ; hsa-mir-144-3p ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-623 ; hsa-mir-3682-5p ; hsa-mir-6883-3p ; hsa-mir-4699-3p ; hsa-mir-627-3p ; hsa-mir-204-5p ; hsa-mir-211-5p ; hsa-mir-1305 ; hsa-mir-335-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-12113/Upstream/7191183; hsa-mir-1243/Downstream/415515;
Nearest TSS
ENST00000502981/Upstream/1342085; ENST00000502245/Downstream/35183;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/5287631, chr4-CpG: 100/Downstream/233158
Upstream sequence
acaaacccataaccctagactaatcatgagaaaaatatcagacaaatcacaattgagaaacattctacaaaatgtctgaccactactcaaaactgtcaag
Downstream sequence
tgccaaatgaattgtgTTATATATCTTGGTGCCTTGTGTCAAACATGTTTTACAAAATATTGCCCAAGTATTTTATCAAACTTTTGTATAATTCATAATG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate