Basic Information
VIS ID
TVIS20001285
Fusion event
HPV-EPHA5 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
66531972/65666254 (Hg38)
End
66531972/65666254 (Hg38)
Location type
Intronic
Target gene
EPHA5
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-181a-5p ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-297 ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-5011-5p
Nearest miRNA
hsa-mir-12113/Upstream/4743570; hsa-mir-1243/Downstream/610570;
Nearest TSS
ENST00000502981/Upstream/641769; ENST00000509473/Downstream/3681;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/2316388, chr4-CpG: 32/Downstream/3221
Upstream sequence
catgttgttatggcagatttcagtttcttacagtctgggactgaggctgtcagatcctacaggtcactcttgcttgcctgacatgtggccctgtctgtct
Downstream sequence
AAACTGCTGACAACTGTCAGAAGCACTTTACTGGGACATTACTGACTGTAGCTTCAATGAATTAAGCTTGATTCACTGCGGGTGAATCATTTTCAATGCA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate