Basic Information
VIS ID
TVIS20001311
Fusion event
HPV-SNX18 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
53870527/54574697 (Hg38)
End
53870527/54574697 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
SNX18
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-193b-3p ; hsa-mir-4528 ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-3714 ; hsa-mir-3910 ; hsa-mir-548e-5p ; hsa-mir-506-3p
Nearest miRNA
hsa-mir-10397/Upstream/623098; hsa-mir-103a-1/Downstream/595835;
Nearest TSS
ENST00000502646/Upstream/56832; ENST00000512089/Downstream/383149;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/55221, chr5-CpG: 84/Downstream/308838
Upstream sequence
CATGGAATTTTGCCTGAGATGATGTGAAAGGCACCACCTGCAGAaggtgggagaatggctttccaggcagagagaagggtggagcagaagcactcagcgt
Downstream sequence
TAAGGAACGAGAACCAGCAGGCTCTGAGATGACTTGGGCTGCCATGTTTGGGGATGTGTGTAGGGGCGGGTAAGGGTGTACATGTATGAAGGGCTGGAAC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate