Basic Information
VIS ID
TVIS20001316
Fusion event
HPV-IQGAP2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr5
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
75756150/76460325 (Hg38)
End
75756150/76460325 (Hg38)
Location type
Intronic
Target gene
IQGAP2
miRNAs that regulate target gene
hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-549a ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-548e-5p ; hsa-mir-92a-1-5p
Nearest miRNA
hsa-mir-10397/Upstream/3581662; hsa-mir-103a-1/Downstream/6379830;
Nearest TSS
ENST00000502646/Upstream/55901; ENST00000504815/Downstream/87084;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/55990, chr5-CpG: 111/Downstream/254970
Nearest cancer related gene
IQGAP2(TSG, No orient, 0)
Upstream sequence
tccatttacatgaagttttgtaacagccaaactagtcttgaatgataggaattaggacaatggctgcctctgatggtggatgggtgagaggaattaactg
Downstream sequence
tggagggagtggtgtggtcctggaacaCGGTGCTGCCTGGGAGCTCTGGCTAAAGTGTGGGCTTCCTGGATGTGGGGAGATGCAAAGTGCTCTAGAACTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate