Basic Information
VIS ID
TVIS20001335
Fusion event
HPV-QRSL1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr6
Cytoband
q21
Reference genome
GRCh37/hg19
Start
107110283/106662408 (Hg38)
End
107110283/106662408 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA6F
Target gene
QRSL1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-769-5p ; hsa-mir-200b-3p ; hsa-mir-3127-5p ; hsa-mir-6754-5p ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-211-3p ; hsa-mir-759 ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-892c-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6760-5p ; hsa-mir-10a-3p ; hsa-mir-4284 ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-7113-5p ; hsa-mir-6823-5p ; hsa-mir-6890-3p ; hsa-mir-1306-5p
Nearest miRNA
hsa-mir-10398/Upstream/7537712; hsa-mir-1202/Downstream/121717;
Nearest TSS
ENST00000381078/Upstream/32794; ENST00000424162/Downstream/33127;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/149298, chr6-CpG: 236/Downstream/310932
Upstream sequence
agtggctcaagtctgtaatctcagcactttgggaggctgaggtaggtggatcacctgatgtcaggagtttgagaccagcctggccaacatgacaaaaccc
Downstream sequence
GCAACACAGTGGAAGAGAATTCATTTTTATGTTAAGAATCTTAATGGTGCCTCCTCATAAAAGCCAAGAATCCAGTGGTTCTTTTTTTTTTTTTTTCCCT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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