Basic Information
VIS ID
TVIS20001352
Fusion event
HPV-PSPH integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
56081544/56013851 (Hg38)
End
56081544/56013851 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7A
Target gene
PSPH
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-16-5p ; hsa-mir-296-3p ; hsa-mir-4444 ; hsa-mir-5696 ; hsa-mir-340-5p ; hsa-mir-496 ; hsa-mir-3691-3p ; hsa-mir-4729 ; hsa-mir-3163 ; hsa-mir-1208 ; hsa-mir-1303 ; hsa-mir-1304-3p ; hsa-mir-3658 ; hsa-mir-483-5p ; hsa-mir-6760-3p ; hsa-mir-7856-5p
Nearest miRNA
hsa-mir-1183/Upstream/11132051; hsa-mir-10399/Downstream/941934;
Nearest TSS
ENST00000635602/Upstream/32080; ENST00000493855/Downstream/20305;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/48641, chr7-CpG: 105/Downstream/37501
Upstream sequence
TCAAAGTTTGGGAGAAAGGGAGACATTGTAATTGACAGAGGCACCATAACGTGGTGGGATTCAAAAGAAGGGTTACCCTCAGCGTTCCCAAACTTTGTAT
Downstream sequence
catggtggttcatacctgtgataccagcactttgggaggccaaagcaggggagatcgcttgagctcaggaatttgagaccagcctgggaaatatagcata
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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