Basic Information
VIS ID
TVIS20001356
Fusion event
HPV-DGKI integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr7
Cytoband
q33
Reference genome
GRCh37/hg19
Start
137429616/137744870 (Hg38)
End
137429616/137744870 (Hg38)
Location type
Intronic
Target gene
DGKI
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-127-5p ; hsa-mir-7843-3p ; hsa-mir-4786-3p ; hsa-mir-4635 ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p
Nearest miRNA
hsa-mir-10525/Upstream/841576; hsa-mir-10399/Downstream/378888;
Nearest TSS
ENST00000635602/Upstream/54866; ENST00000418554/Downstream/29779;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/580271, chr7-CpG: 117/Downstream/101509
Upstream sequence
tgttgaaagtctttttaattttaattattttggtgggtatttcattgtggttttatttgtatcttcctgattgaccagggttgattaatgttgcatgtgc
Downstream sequence
taggtatcaagaaaaatatctgaaaataataagagccctatatgacaaactcacagccaacatcatgctgaatgtgcaaaagttggaagcattcccccta
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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