Basic Information
VIS ID
TVIS20001357
Fusion event
HPV-KIAA1549 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr7
Cytoband
q34
Reference genome
GRCh37/hg19
Start
138628033/138943287 (Hg38)
End
138628033/138943287 (Hg38)
Location type
Intronic
Target gene
KIAA1549
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-29c-3p ; hsa-mir-148a-3p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-4705 ; hsa-mir-218-5p ; hsa-mir-4701-5p ; hsa-mir-129-5p ; hsa-mir-3149 ; hsa-mir-500b-3p ; hsa-mir-1266-3p ; hsa-mir-888-3p ; hsa-mir-200a-3p ; hsa-mir-141-3p ; hsa-mir-1306-5p ; hsa-mir-1303 ; hsa-mir-3674 ; hsa-mir-744-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-4732-5p ; hsa-mir-6832-5p ; hsa-mir-4781-3p ; hsa-mir-483-5p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-7156-3p ; hsa-mir-6861-3p ; hsa-mir-1184 ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-3620-3p ; hsa-mir-6865-3p ; hsa-mir-4700-3p ; hsa-mir-5089-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-150-5p ; hsa-mir-186-3p ; hsa-mir-4698 ; hsa-mir-6504-3p ; hsa-mir-4438
Nearest miRNA
hsa-mir-10525/Upstream/819466; hsa-mir-10399/Downstream/100813;
Nearest TSS
ENST00000635602/Upstream/143727; ENST00000479132/Downstream/38031;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/73534, chr7-CpG: 150/Downstream/37678
Upstream sequence
ttctgttttttcaaataaaatgtttACAGAAAAAGAGAAAATAAAGTTGGAATTTATATCTAGAAAAAGGAGGAGACAAAGAAAACTCTAAAGGCAGTAA
Downstream sequence
agagaggtctggtttgcccaaatccctgccagagaatctggactagagccctgggctgtctgcccccagcgccggcagtctcagtcacAGCACACGAAAC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate