Basic Information
VIS ID
TVIS20001366
Fusion event
HPV-SNX16 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chr8
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
82733073/81820838 (Hg38)
End
82733073/81820838 (Hg38)
Location type
Intronic
Target gene
SNX16
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-103a-3p ; hsa-mir-96-5p ; hsa-mir-16-5p ; hsa-mir-1277-5p ; hsa-mir-140-5p ; hsa-mir-195-5p ; hsa-mir-93-5p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-202-5p ; hsa-mir-337-3p ; hsa-mir-3927-5p ; hsa-mir-4519 ; hsa-mir-7849-3p ; hsa-mir-548e-5p ; hsa-mir-424-5p ; hsa-mir-6838-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-497-5p ; hsa-mir-4666a-3p
Nearest miRNA
hsa-mir-12123/Upstream/1579365; hsa-mir-10400/Downstream/9384647;
Nearest TSS
ENST00000518652/Upstream/29015; ENST00000534675/Downstream/3012;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/88224, chr8-CpG: 44/Downstream/20981
Upstream sequence
gccatgaagccagtcctggctgggggcttcagacacaaagggagtgcccattctctagaaagttcttcctcctcacccttcactaggtgttcaggaggac
Downstream sequence
TCCCCTCTTTTATACCCTTTAACACAGGGCAAATGCATAAGATTTGCTCTGTATGAATAACCCTTCCTCCTCTTCTCTGACTCACATTTTAAGCAATATG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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