Basic Information
VIS ID
TVIS20001391
Fusion event
HPV-DMD integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chrX
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
33228506/33210389 (Hg38)
End
33228506/33210389 (Hg38)
Location type
Intronic
Target gene
DMD
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-31-5p ; hsa-mir-155-5p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-4446-5p ; hsa-mir-186-3p ; hsa-mir-561-3p ; hsa-mir-6499-3p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-297 ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-8068 ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-3973 ; hsa-mir-511-3p ; hsa-mir-9-3p
Nearest miRNA
hsa-mir-23c/Upstream/568830; hsa-let-7f-2/Downstream/4813506;
Nearest TSS
ENST00000429181/Upstream/81312; ENST00000445233/Downstream/923;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1943487, chrX-CpG: 36/Downstream/515924
Nearest cancer related gene
DMD(TSG, No orient, 0)
Upstream sequence
TATGTGCTGTATAATTCCAAGATGTTGTAAATAAGTTTGCTCAAATAGCTTTCTCTACTTCTTCAGTGGGGTTTGAAGTTCAACAATTCTGAGCGTATCC
Downstream sequence
GTCCTTATCATATATTATTTTTACTGTTGTGCCACAGTCCATTTTTAAATCCTTCATTAGTCATCATGACTTTCTTAAAAATAAACGAAATAGTTGTATT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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