Basic Information
VIS ID
TVIS20001409
Fusion event
HPV-F9 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537777.1
Host Sequence
Chromosome
chrX
Cytoband
q27.1
Reference genome
GRCh37/hg19
Start
138621560/139539401 (Hg38)
End
138621560/139539401 (Hg38)
Location type
Intronic
Target gene
F9
miRNAs that regulate target gene
hsa-mir-4298 ; hsa-mir-1302 ; hsa-mir-4314 ; hsa-mir-3191-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-3192-5p ; hsa-mir-4646-5p ; hsa-mir-204-3p ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-518c-5p ; hsa-mir-342-3p ; hsa-mir-6890-3p ; hsa-mir-216b-3p ; hsa-mir-7106-3p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-6845-3p
Nearest miRNA
hsa-let-7f-2/Upstream/871608; hsa-mir-105-1/Downstream/384747;
Nearest TSS
ENST00000429181/Upstream/8636; ENST00000643157/Downstream/5280;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/92259, chrX-CpG: 41/Downstream/152697
Upstream sequence
TACACTAAAATTCTCAGTAATTCAAACGTAAAAGCAACATGAGCAAGGGATTTTGGACTGATGGGACCCAGACTAGCTAACATTTTGATTTAAAAGAAAA
Downstream sequence
TATTCATTAAACAGGAACCTGGTAGTCTTAAACAGGAATCTCTCACTTGGTAAGATCTTGTCTCTTGTTGTATTTGACCCCAACTGTCTATGGCTTTGCC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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