Basic Information
VIS ID
TVIS20001416
Fusion event
HPV-OSBPL9 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
52128314/51662642 (Hg38)
End
52128314/51662642 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1B
Target gene
OSBPL9
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-296-3p ; hsa-mir-125a-5p ; hsa-mir-190a-3p ; hsa-mir-297 ; hsa-mir-3924 ; hsa-mir-5011-5p ; hsa-mir-6867-5p ; hsa-mir-6083 ; hsa-mir-223-5p ; hsa-mir-567 ; hsa-mir-511-3p ; hsa-mir-574-5p ; hsa-mir-4642 ; hsa-mir-3713 ; hsa-mir-4711-5p ; hsa-mir-4740-3p
Nearest miRNA
hsa-mir-12136/Upstream/602539; hsa-mir-101-1/Downstream/173702;
Nearest TSS
ENST00000473358/Upstream/45528; ENST00000467064/Downstream/51361;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/45266, chr1-CpG: 68/Downstream/66714
Upstream sequence
ttttcagcataacatgttctaagttcactttatatttcctctgcccaacattcaaaatcatacacctttcctagaaagtctgattatttttaaagcagaa
Downstream sequence
taaaatttagaactcaagaACCATGAAGTATTGGTAATAGATGGGAATGTCCAATACTTTGGAAATATAATTATTTTCAGGGATTTTTGGTGGTAAAATC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate