Basic Information
VIS ID
TVIS20001434
Fusion event
HPV-CDK18 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
205494686/205525558 (Hg38)
End
205494686/205525558 (Hg38)
Location type
Intronic
Target gene
CDK18
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-222-3p ; hsa-mir-4722-5p ; hsa-mir-5695 ; hsa-mir-4673 ; hsa-mir-4514 ; hsa-mir-4692 ; hsa-mir-6736-3p ; hsa-mir-6893-5p ; hsa-mir-940 ; hsa-mir-6808-5p
Nearest miRNA
hsa-mir-101-1/Upstream/77160; hsa-mir-1182/Downstream/949245;
Nearest TSS
ENST00000473358/Upstream/1998; ENST00000506489/Downstream/1852;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/20577, chr1-CpG: 44/Downstream/3317
Upstream sequence
tggttcaaattacattatgaaattcctatagttaatttttcacttccagaagttctatttggttttttcttgaaatggctttgtcacatttcaactcttt
Downstream sequence
ggttgtttactgctgtccttatattggtttaagcctcttcctatatcttgttgaactgccttgtcctctagattctgaattctatatctattatgtcagc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate